Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (28 [9])

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Volume 28, Issue 9; September 1, 2008

In Memoriam
Editorials
Brief Reviews
Integrative Physiology/Experimental Medicine
Cell Biology/Signaling
Letters to the Editor
Clinical and Population Studies

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	In Memoriam
	Ross Gerrity, 1945–2008 J.A. Berliner and C.C. Hedrick Arterioscler Thromb Vasc Biol. 2008;28:e155, doi:10.1161/ATVBAHA.108.174268 Full Text \| PDF
	Basil Rifkind David J. Gordon Arterioscler Thromb Vasc Biol. 2008;28:e156, doi:10.1161/ATVBAHA.108.174078 Full Text \| PDF
	Editorials
	VEGF-B Taken to Our Hearts: Specific Effect of VEGF-B in Myocardial Ischemia Lena Claesson-Welsh Arterioscler Thromb Vasc Biol. 2008;28:1575-1576, doi:10.1161/ATVBAHA.108.170878 Full Text \| PDF
	NO Targets SIRT1: A Novel Signaling Network in Endothelial Senescence Michael Potente and Stefanie Dimmeler Arterioscler Thromb Vasc Biol. 2008;28:1577-1579, doi:10.1161/ATVBAHA.108.173682 Full Text \| PDF
	Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNOS-Dependent Nitric Oxide Production, Not Uncoupled eNOS Activity Hao Xu and Kirkwood A. Pritchard, Jr Arterioscler Thromb Vasc Biol. 2008;28:1580-1581, doi:10.1161/ATVBAHA.108.171801 Full Text \| PDF
	Is LDL-C Passed Its Prime?: The Emerging Role of Non-HDL, LDL-P, and ApoB in CHD Risk Assessment Michael H. Davidson Arterioscler Thromb Vasc Biol. 2008;28:1582-1583, doi:10.1161/ATVBAHA.108.172718 Full Text \| PDF
	Brief Reviews
	Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells Karen K. Hirschi, David A. Ingram, and Mervin C. Yoder Arterioscler Thromb Vasc Biol. 2008;28:1584-1595; published online before print July 31 2008, doi:10.1161/ATVBAHA.107.155960 Full Text \| PDF
	Murine Models of Hyperhomocysteinemia and Their Vascular Phenotypes Sanjana Dayal and Steven R. Lentz Arterioscler Thromb Vasc Biol. 2008;28:1596-1605; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.166421 Abstract \| Full Text \| PDF
	Integrative Physiology/Experimental Medicine
	Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice Jian-Xiong Chen and Amanda Stinnett Arterioscler Thromb Vasc Biol. 2008;28:1606-1613; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.169235 Abstract \| Full Text \| PDF \| Data Supplement
	Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium Xuri Li, Marc Tjwa, Inge Van Hove, Berndt Enholm, Elke Neven, Karri Paavonen, Michael Jeltsch, Toni Diez Juan, Richard E. Sievers, Emmanuel Chorianopoulos, Hiromichi Wada, Maarten Vanwildemeersch, Agnes Noel, Jean-Michel Foidart, Matthew L. Springer, Georges von Degenfeld, Mieke Dewerchin, Helen M. Blau, Kari Alitalo, Ulf Eriksson, Peter Carmeliet, and Lieve Moons Arterioscler Thromb Vasc Biol. 2008;28:1614-1620; published online before print May 29 2008, doi:10.1161/ATVBAHA.107.158725 Abstract \| Full Text \| PDF \| Data Supplement Using loss- and gain-of-function approaches, we studied the role of VEGF-B in various models of pathological angiogenesis. VEGF-B appears to have a relatively restricted role in pathological blood vessel formation in the ischemic heart.
	Restoration of Plasma von Willebrand Factor Deficiency Is Sufficient to Correct Thrombus Formation After Gene Therapy for Severe von Willebrand Disease Simon F. De Meyer, Nele Vandeputte, Inge Pareyn, Inge Petrus, Peter J. Lenting, Marinee K.L. Chuah, Thierry VandenDriessche, Hans Deckmyn, and Karen Vanhoorelbeke Arterioscler Thromb Vasc Biol. 2008;28:1621-1626; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.168369 Abstract \| Full Text \| PDF \| Data Supplement To investigate the feasibility of ectopic vWF expression by targeting the liver, vWF liver gene transfer was established in vWD mice. Multimerized vWF was expressed that could restore proper platelet plug formation in severe vWD, suggesting that the liver is an attractive target for gene therapy for severe vWD.
	Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase Qian Zhang, Pulkit Malik, Deepesh Pandey, Sonali Gupta, Davin Jagnandan, Eric Belin de Chantemele, Botond Banfi, Mario B. Marrero, R. Daniel Rudic, David W. Stepp, and David J.R. Fulton Arterioscler Thromb Vasc Biol. 2008;28:1627-1633; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.168278 Abstract \| Full Text \| PDF \| Data Supplement
	Cell Biology/Signaling
	Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells Hidetaka Ota, Masato Eto, Mitsunobu R. Kano, Sumito Ogawa, Katsuya Iijima, Masahiro Akishita, and Yasuyoshi Ouchi Arterioscler Thromb Vasc Biol. 2008;28:1634-1639; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.164368 Abstract \| Full Text \| PDF \| Data Supplement
	ECSM2, An Endothelial Specific Filamin A Binding Protein That Mediates Chemotaxis Laura-Jane Armstrong, Victoria L. Heath, Sharon Sanderson, Sukhbir Kaur, James F.J. Beesley, John M.J. Herbert, John A. Legg, Richard Poulsom, and Roy Bicknell Arterioscler Thromb Vasc Biol. 2008;28:1640-1646; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.162511 Abstract \| Full Text \| PDF \| Data Supplement Expression of a novel endothelial specific gene called ECSM2 has been characterized in vitro and in vivo. ECSM2 is a transmembrane protein with no homology to known proteins that regulates endothelial tube formation and chemotaxis in vitro, and couples to filamin-A.
	Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages Jason L. Johnson, Graciela B. Sala-Newby, Yasmin Ismail, Concepción M. Aguilera, and Andrew C. Newby Arterioscler Thromb Vasc Biol. 2008;28:1647-1653; published online before print June 19 2008, doi:10.1161/ATVBAHA.108.170548 Abstract \| Full Text \| PDF \| Data Supplement We report here that a subset of rabbit foam-cell macrophages exhibits reduced TIMP-3/MT1-MMP balance and is highly invasive, proliferative, and prone to undergo apoptosis, characteristics associated with plaque instability. Foam-cell macrophages lacking TIMP-3 and overexpressing MMP-14 were also identified in advanced human plaques, underlying their potential proatherogenic role.
	Letters to the Editor
	Patterns of USPIO Deposition in Murine Atherosclerosis G. Klug, L. Bauer, and W.R. Bauer Arterioscler Thromb Vasc Biol. 2008;28:e157, doi:10.1161/ATVBAHA.108.170506 Full Text \| PDF
	Patterns of USPIO Deposition in Murine Atherosclerosis Joanne B. Morris, Alan R. Olzinski, and Beat M. Jucker Arterioscler Thromb Vasc Biol. 2008;28:e158-e159, doi:10.1161/ATVBAHA.108.170704 Full Text \| PDF
	Clinical and Population Studies
	Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects Caroline M. Apovian, Sherman Bigornia, Melanie Mott, Melissa R. Meyers, Jagadish Ulloor, Manana Gagua, Marie McDonnell, Donald Hess, Lija Joseph, and Noyan Gokce Arterioscler Thromb Vasc Biol. 2008;28:1654-1659; published online before print June 19 2008, doi:10.1161/ATVBAHA.108.170316 Abstract \| Full Text \| PDF
	Triglyceride-Rich Lipoprotein-Associated Apolipoprotein C-III Production Is Stimulated by Plasma Free Fatty Acids in Humans Mirjana Pavlic, René Valéro, Hélène Duez, Changting Xiao, Linda Szeto, Bruce W. Patterson, and Gary F. Lewis Arterioscler Thromb Vasc Biol. 2008;28:1660-1665; published online before print June 12 2008, doi:10.1161/ATVBAHA.108.169383 Abstract \| Full Text \| PDF \| Data Supplement The mechanism of the increase in triglyceride-rich lipoprotein (TRL) apoC-III concentration and production in insulin resistant states is not known. We investigated this phenomenon in healthy men using stable isotope enrichment methodology, and demonstrated that TRL apoC-III production is stimulated by an acute elevation of plasma FFAs.
	Lipoprotein Particle Concentrations May Explain the Absence of Coronary Protection in the Women’s Health Initiative Hormone Trials Judith Hsia, James D. Otvos, Jacques E. Rossouw, LieLing Wu, Sylvia Wassertheil-Smoller, Susan L. Hendrix, Jennifer G. Robinson, Bernedine Lund, Lewis H. Kuller for the Women’s Health Initiative Research Group Arterioscler Thromb Vasc Biol. 2008;28:1666-1671; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.170431 Abstract \| Full Text \| PDF In the Women's Health Initiative randomized trials, postmenopausal hormone therapy raised high density lipoprotein-cholesterol and particle concentration and reduced low density lipoprotein-cholesterol (P<0.001 versus placebo). Neither unopposed estrogen nor estrogen with progestin lowered low density lipoprotein particle concentration.
	Extended-Release Niacin Alters the Metabolism of Plasma Apolipoprotein (Apo) A-I and ApoB-Containing Lipoproteins Stefania Lamon-Fava, Margaret R. Diffenderfer, P. Hugh R. Barrett, Aaron Buchsbaum, Mawuli Nyaku, Katalin V. Horvath, Bela F. Asztalos, Seiko Otokozawa, Masumi Ai, Nirupa R. Matthan, Alice H. Lichtenstein, Gregory G. Dolnikowski, and Ernst J. Schaefer Arterioscler Thromb Vasc Biol. 2008;28:1672-1678; published online before print June 19 2008, doi:10.1161/ATVBAHA.108.164541 Abstract \| Full Text \| PDF \| Data Supplement We investigated the effects of niacin (2 g/d), without or with lovastatin (40 mg/d) on apolipoprotein kinetics in 5 subjects. Niacin treatment significantly increased HDL apoA-I concentrations and production, as well as enhanced clearance of TG-rich lipoprotein apoB-100 and apoB-48. The addition of lovastatin to niacin further promoted an enhanced clearance of LDL apoB-100.
	Coronary Artery Disease–Associated Locus on Chromosome 9p21 and Early Markers of Atherosclerosis Nilesh J. Samani, Olli T. Raitakari, Kalle Sipilä, Martin D. Tobin, Heribert Schunkert, Markus Juonala, Peter S. Braund, Jeanette Erdmann, Jorma Viikari, Leena Moilanen, Leena Taittonen, Antti Jula, Eero Jokinen, Tomi Laitinen, Nina Hutri-Kähönen, Markku S. Nieminen, Y. Antero Kesäniemi, Alistair S. Hall, Janne Hulkkonen, Mika Kähönen, and Terho Lehtimäki Arterioscler Thromb Vasc Biol. 2008;28:1679-1683; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.170332 Abstract \| Full Text \| PDF We examined the association with carotid intima-media thickness and brachial flow mediated dilatation of the recently identified susceptibility locus for coronary artery disease on chromosome 9p21. We found no evidence that the risk variant affects either of these early markers of atherosclerosis, suggesting an alternate mechanism for its effect on risk of CAD.

Spotlight

TOC Spotlight File

Volume 28, Issue 9; September 1, 2008

In Memoriam

Ross Gerrity, 1945–2008

Basil Rifkind

Editorials

VEGF-B Taken to Our Hearts: Specific Effect of VEGF-B in Myocardial Ischemia

NO Targets SIRT1: A Novel Signaling Network in Endothelial Senescence

Targeted Increases in Endothelial Cell Superoxide Anion Production Stimulate eNOS-Dependent Nitric Oxide Production, Not Uncoupled eNOS Activity

Is LDL-C Passed Its Prime?: The Emerging Role of Non-HDL, LDL-P, and ApoB in CHD Risk Assessment

Brief Reviews

Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells

Murine Models of Hyperhomocysteinemia and Their Vascular Phenotypes

Integrative Physiology/Experimental Medicine

Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice

Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium

Restoration of Plasma von Willebrand Factor Deficiency Is Sufficient to Correct Thrombus Formation After Gene Therapy for Severe von Willebrand Disease

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

Cell Biology/Signaling

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

ECSM2, An Endothelial Specific Filamin A Binding Protein That Mediates Chemotaxis

Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages

Letters to the Editor

Patterns of USPIO Deposition in Murine Atherosclerosis

Patterns of USPIO Deposition in Murine Atherosclerosis

Clinical and Population Studies

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

Triglyceride-Rich Lipoprotein-Associated Apolipoprotein C-III Production Is Stimulated by Plasma Free Fatty Acids in Humans

Lipoprotein Particle Concentrations May Explain the Absence of Coronary Protection in the Women’s Health Initiative Hormone Trials

Extended-Release Niacin Alters the Metabolism of Plasma Apolipoprotein (Apo) A-I and ApoB-Containing Lipoproteins

Coronary Artery Disease–Associated Locus on Chromosome 9p21 and Early Markers of Atherosclerosis

Spotlight